Bioavailability and Lag¶
[Generated automatically as a Fitting summary]
Inputs¶
Description¶
| Name: | biolag_abs_bio |
|---|---|
| Title: | Bioavailability and Lag |
| Author: | Wright Dose Ltd |
| Abstract: |
One compartment model absorption dosing with bioavailability and lag parameters.
| Keywords: | identifiability; bioavailability; lag |
|---|---|
| Input Script: | biolag_abs_bio_fit.pyml |
| Input Data: | synthetic_data.csv |
| Diagram: |
Initial fixed effect estimates¶
f[KA] = 0.5
f[CL] = 1
f[V] = 15
f[ANOISE_STD] = 5
f[BIO] = 1
f[LAG] = 1
Outputs¶
Final fitted fixed effects¶
f[KA] = 0.4038
f[CL] = 2.624
f[V] = 16.15
f[ANOISE_STD] = 0.90055
f[BIO] = 1
f[LAG] = 0.0016455
Fitted parameter .csv files¶
| Fixed Effects: | fx_params.csv (fit) |
|---|---|
| Random Effects: | rx_params.csv (fit) |
| Model params: | mx_params.csv (fit) |
| State values: | sx_params.csv (fit) |
| Predictions: | px_params.csv (fit) |
Plots¶
Comparison¶
Compare Main f[X]¶
| Variable Name | Fitted Value | Starting Value | Prop Change | Abs Change |
|---|---|---|---|---|
| f[KA] | 0.403799 | 0.5 | 0.192401 | 0.0962005 |
| f[CL] | 2.62398 | 1 | 1.62398 | 1.62398 |
| f[V] | 16.1504 | 15 | 0.0766966 | 1.15045 |
| f[BIO] | 1 | 1 | 0 | 0 |
| f[LAG] | 0.00164553 | 1 | 0.998354 | 0.998354 |
Compare Noise f[X]¶
| Variable Name | Fitted Value | Starting Value | Prop Change | Abs Change |
|---|---|---|---|---|
| f[ANOISE_STD] | 0.900547 | 5 | 0.819891 | 4.09945 |