Bioavailability and Lag¶
[Generated automatically as a Fitting summary]
Inputs¶
Description¶
| Name: | biolag_abs_lag |
|---|---|
| Title: | Bioavailability and Lag |
| Author: | Wright Dose Ltd |
| Abstract: |
One compartment model absorption dosing with bioavailability and lag parameters.
| Keywords: | identifiability; bioavailability; lag; dep_one_cmp_cl |
|---|---|
| Input Script: | biolag_abs_lag_fit.pyml |
| Input Data: | synthetic_data.csv |
| Diagram: |
Initial fixed effect estimates¶
f[KA] = 0.5000
f[CL] = 1.0000
f[V] = 15.0000
f[ANOISE_STD] = 5.0000
f[BIO] = 1.0000
f[LAG] = 1.0000
Outputs¶
Final fitted fixed effects¶
f[KA] = 1.0000
f[CL] = 3.2273
f[V] = 22.5113
f[ANOISE_STD] = 0.8915
f[BIO] = 1.0000
f[LAG] = 8.6654
Fitted parameter .csv files¶
| Fixed Effects: | fx_params.csv (fit) |
|---|---|
| Random Effects: | rx_params.csv (fit) |
| Model params: | mx_params.csv (fit) |
| State values: | sx_params.csv (fit) |
| Predictions: | px_params.csv (fit) |
Plots¶
Comparison¶
Compare Main f[X]¶
| Variable Name | Fitted Value | Starting Value | Prop Change | Abs Change |
|---|---|---|---|---|
| f[KA] | 1.0000 | 0.5000 | 1.0000 | 0.5000 |
| f[CL] | 3.2273 | 1.0000 | 2.2273 | 2.2273 |
| f[V] | 22.5113 | 15.0000 | 0.5008 | 7.5113 |
| f[BIO] | 1.0000 | 1.0000 | 0.0000 | 0.0000 |
| f[LAG] | 8.6654 | 1.0000 | 7.6654 | 7.6654 |
Compare Noise f[X]¶
| Variable Name | Fitted Value | Starting Value | Prop Change | Abs Change |
|---|---|---|---|---|
| f[ANOISE_STD] | 0.8915 | 5.0000 | 0.8217 | 4.1085 |