:orphan: 





.. _biolag_abs_both_fit:



Bioavailability and Lag
#######################

[Generated automatically as a Fitting summary]

Inputs
******



Description
===========

:Name: biolag_abs_both

:Title: Bioavailability and Lag

:Author: Wright Dose Ltd

:Abstract: 

| One compartment model absorption dosing with bioavailability and lag parameters.

:Keywords: identifiability; bioavailability; lag

:Input Script: :download:`biolag_abs_both_fit.pyml <biolag_abs_both_fit.pyml>`

:Input Data: :download:`synthetic_data.csv <synthetic_data.csv>`

:Diagram: 


.. thumbnail:: biolag_abs_both_fit.pyml_output/fit/compartment_diagram.svg
    :width: 200px


Initial fixed effect estimates
==============================

.. code-block:: pyml

    f[KA] = 0.5000
    f[CL] = 1.0000
    f[V] = 15.0000
    f[ANOISE_STD] = 5.0000
    f[BIO] = 1.0000
    f[LAG] = 1.0000



Outputs
*******



Final objective value
=====================

.. code-block:: pyml

    77.0130


which required 7 iterations and took 0.33 seconds

Final fitted fixed effects
==========================

.. code-block:: pyml

    f[KA] = 1.0000
    f[CL] = 9.8758
    f[V] = 99.3712
    f[ANOISE_STD] = 1.3101
    f[BIO] = 1.0000
    f[LAG] = 16115163387053897220730226759446954961843257344.0000



Fitted parameter .csv files
===========================


:Fixed Effects: :download:`fx_params.csv (fit) <biolag_abs_both_fit.pyml_output/fit/solN/fx_params.csv>`

:Random Effects: :download:`rx_params.csv (fit) <biolag_abs_both_fit.pyml_output/fit/solN/rx_params.csv>`

:Model params: :download:`mx_params.csv (fit) <biolag_abs_both_fit.pyml_output/fit/solN/mx_params.csv>`

:State values: :download:`sx_params.csv (fit) <biolag_abs_both_fit.pyml_output/fit/solN/sx_params.csv>`

:Predictions: :download:`px_params.csv (fit) <biolag_abs_both_fit.pyml_output/fit/solN/px_params.csv>`



Plots
*****



Dense sim plots
===============



.. thumbnail:: images/fit_dense/000001.svg
    :width: 200px


Alternatively see :ref:`biolag_abs_both_dense_sim_plots`

Comparison
**********



Compare Main f[X]
=================


===============  ====================================================  ================  ====================================================  ====================================================
Variable Name                                            Fitted Value    Starting Value                                           Prop Change                                            Abs Change
===============  ====================================================  ================  ====================================================  ====================================================
f[KA]                                                          1.0000            0.5000                                                1.0000                                                0.5000
f[CL]                                                          9.8758            1.0000                                                8.8758                                                8.8758
f[V]                                                          99.3712           15.0000                                                5.6247                                               84.3712
f[BIO]                                                         1.0000            1.0000                                                0.0000                                                0.0000
f[LAG]           16115163387099999137759327006320587064016371712.0000            1.0000  16115163387099999137759327006320587064016371712.0000  16115163387099999137759327006320587064016371712.0000
===============  ====================================================  ================  ====================================================  ====================================================

Compare Noise f[X]
==================


===============  ==============  ================  =============  ============
Variable Name      Fitted Value    Starting Value    Prop Change    Abs Change
===============  ==============  ================  =============  ============
f[ANOISE_STD]            1.3101            5.0000         0.7380        3.6899
===============  ==============  ================  =============  ============

Compare Variance f[X]
=====================


