Bioavailability and Lag¶
[Generated automatically as a Fitting summary]
Inputs¶
Description¶
| Name: | biolag_abs_bio |
|---|---|
| Title: | Bioavailability and Lag |
| Author: | Wright Dose Ltd |
| Abstract: |
One compartment model absorption dosing with bioavailability and lag parameters.
| Keywords: | identifiability; bioavailability; lag |
|---|---|
| Input Script: | biolag_abs_bio_fit.pyml |
| Input Data: | synthetic_data.csv |
| Diagram: |
Initial fixed effect estimates¶
f[KA] = 0.5000
f[CL] = 1.0000
f[V] = 15.0000
f[ANOISE_STD] = 5.0000
f[BIO] = 0.8000
f[LAG] = 1.0000
Outputs¶
Final fitted fixed effects¶
f[KA] = 1.0000
f[CL] = 7.9815
f[V] = 88.3378
f[ANOISE_STD] = 1.1181
f[BIO] = 0.0000
f[LAG] = 556991931180618173920440774875204562471103574122168320.0000
Fitted parameter .csv files¶
| Fixed Effects: | fx_params.csv (fit) |
|---|---|
| Random Effects: | rx_params.csv (fit) |
| Model params: | mx_params.csv (fit) |
| State values: | sx_params.csv (fit) |
| Predictions: | px_params.csv (fit) |
Plots¶
Comparison¶
Compare Main f[X]¶
| Variable Name | Fitted Value | Starting Value | Prop Change | Abs Change |
|---|---|---|---|---|
| f[KA] | 1.0000 | 0.5000 | 1.0000 | 0.5000 |
| f[CL] | 7.9815 | 1.0000 | 6.9815 | 6.9815 |
| f[V] | 88.3378 | 15.0000 | 4.8892 | 73.3378 |
| f[BIO] | 0.0000 | 0.8000 | 1.0000 | 0.8000 |
| f[LAG] | 556991931180999970736126067831210468780642018055421952.0000 | 1.0000 | 556991931180999970736126067831210468780642018055421952.0000 | 556991931180999970736126067831210468780642018055421952.0000 |
Compare Noise f[X]¶
| Variable Name | Fitted Value | Starting Value | Prop Change | Abs Change |
|---|---|---|---|---|
| f[ANOISE_STD] | 1.1181 | 5.0000 | 0.7764 | 3.8819 |