Bioavailability and Lag¶
[Generated automatically as a Fitting summary]
Inputs¶
Description¶
| Name: | biolag_abs_both |
|---|---|
| Title: | Bioavailability and Lag |
| Author: | Wright Dose Ltd |
| Abstract: |
One compartment model absorption dosing with bioavailability and lag parameters.
| Keywords: | identifiability; bioavailability; lag |
|---|---|
| Input Script: | biolag_abs_both_fit.pyml |
| Input Data: | synthetic_data.csv |
| Diagram: |
Initial fixed effect estimates¶
f[KA] = 0.5000
f[CL] = 1.0000
f[V] = 15.0000
f[ANOISE_STD] = 5.0000
f[BIO] = 0.8000
f[LAG] = 1.0000
Outputs¶
Final fitted fixed effects¶
f[KA] = 0.9899
f[CL] = 2.5346
f[V] = 15.4897
f[ANOISE_STD] = 0.8940
f[BIO] = 0.4852
f[LAG] = 8.8987
Fitted parameter .csv files¶
| Fixed Effects: | fx_params.csv (fit) |
|---|---|
| Random Effects: | rx_params.csv (fit) |
| Model params: | mx_params.csv (fit) |
| State values: | sx_params.csv (fit) |
| Predictions: | px_params.csv (fit) |
Plots¶
Comparison¶
Compare Main f[X]¶
| Variable Name | Starting Value | Fitted Value | Prop Change | Abs Change |
|---|---|---|---|---|
| f[KA] | 0.5000 | 0.9899 | 0.9798 | 0.4899 |
| f[CL] | 1.0000 | 2.5346 | 1.5346 | 1.5346 |
| f[V] | 15.0000 | 15.4897 | 0.0326 | 0.4897 |
| f[BIO] | 0.8000 | 0.4852 | 0.3935 | 0.3148 |
| f[LAG] | 1.0000 | 8.8987 | 7.8987 | 7.8987 |
Compare Noise f[X]¶
| Variable Name | Starting Value | Fitted Value | Prop Change | Abs Change |
|---|---|---|---|---|
| f[ANOISE_STD] | 5.0000 | 0.8940 | 0.8212 | 4.1060 |