Bioavailability and Lag¶
[Generated automatically as a Fitting summary]
Inputs¶
Description¶
| Name: | biolag_abs_lag |
|---|---|
| Title: | Bioavailability and Lag |
| Author: | Wright Dose Ltd |
| Abstract: |
One compartment model absorption dosing with bioavailability and lag parameters.
| Keywords: | identifiability; bioavailability; lag; dep_one_cmp_cl |
|---|---|
| Input Script: | biolag_abs_lag_fit.pyml |
| Input Data: | synthetic_data.csv |
| Diagram: |
Initial fixed effect estimates¶
f[KA] = 0.5000
f[CL] = 1.0000
f[V] = 15.0000
f[ANOISE_STD] = 5.0000
f[BIO] = 0.8000
f[LAG] = 1.0000
Outputs¶
Final fitted fixed effects¶
f[KA] = 0.9911
f[CL] = 0.8428
f[V] = 5.9136
f[ANOISE_STD] = 0.8909
f[BIO] = 0.2622
f[LAG] = 8.6494
Fitted parameter .csv files¶
| Fixed Effects: | fx_params.csv (fit) |
|---|---|
| Random Effects: | rx_params.csv (fit) |
| Model params: | mx_params.csv (fit) |
| State values: | sx_params.csv (fit) |
| Predictions: | px_params.csv (fit) |
Plots¶
Comparison¶
Compare Main f[X]¶
| Variable Name | Starting Value | Fitted Value | Prop Change | Abs Change |
|---|---|---|---|---|
| f[KA] | 0.5000 | 0.9911 | 0.9823 | 0.4911 |
| f[CL] | 1.0000 | 0.8428 | 0.1572 | 0.1572 |
| f[V] | 15.0000 | 5.9136 | 0.6058 | 9.0864 |
| f[BIO] | 0.8000 | 0.2622 | 0.6723 | 0.5378 |
| f[LAG] | 1.0000 | 8.6494 | 7.6494 | 7.6494 |
Compare Noise f[X]¶
| Variable Name | Starting Value | Fitted Value | Prop Change | Abs Change |
|---|---|---|---|---|
| f[ANOISE_STD] | 5.0000 | 0.8909 | 0.8218 | 4.1091 |